The stomach is an important organ in the digestive system[10]. Located on the left side of the body in the upper abdominal region, the stomach secretes acids and enzymes required to digest food. Food moves from the mouth into a narrow ‘food pipe’ or oesophagus from where it reaches a muscular, bag-like structure, which is the stomach. The oesophageal sphincter, at the upper end of the stomach, acts as a valve and allows the food into the stomach. A muscular tissue called Rugae line the inside of the stomach. The Rugae contract periodically to churn the food. Subsequently, the food enters the small intestine through a valve, at the lower end of the stomach, called as Pyloric sphincter.
There are various ailments that can affect this vital organ and one of them is stomach cancer. Stomach cancer is the sixth most common type of cancer and affects people of all ages and socio-economic groups. It is good to know more about this ailment so that preventive action or timely medical help can be taken.
Types of Stomach cancers
Adenocarcinoma – Cancer of the cells in the inner-most lining of the stomach. This is the most common type and accounts for about 93% of all cases, worldwide.
Lymphoma: Lymphoma is a generic cancer of the immune systemwhich develops wherever lymphatic tissues are found, including the stomach. Lymphoma[11] of the stomach is quite rare and accounts for about 4% of all stomach cancers.
Carcinoid tumors: These develop in the hormone-producing cells of the stomach. The best part about this type of stomach cancer is that it does not spread to other organs of the body. This accounts for about 3% of stomach cancer incidences.
Causes and Risk Factors for Stomach Cancer
Cancer[12] in general is a condition in which an abnormal mutation occurs in the cells’ DNA. The mutation causes the cell to grow, divide rapidly and continue living at the expense of normal cells which may die. In the process, a tumour is created and it starts spreading within the body. Cancerous cells can break off from the tumour and spread far and wide within the body. When the above process is localized to the stomach, we have the above 3 types of cancers. However, it’s not clear what causes such behaviour or why stomach cancers develop.
There are certain risk factors which can act as triggers for the cancer formation.
Lifestyle related Causes:
Alcohol use and abuse
Tobacco use and abuse
Obesity[13]
Sedentary lifestyle and lack of exercise
Diet rich in smoked, salted and pickled food
Diet rich in meat
Diet low in fresh fruits and vegetables
Not storing or cooking food properly
Environmental exposure to dust and fumes
Working in industries that process coal, metal, timber, rubber, lead orasbestos
Genetic causes:
Family history of stomach cancer
Li-Fraumeni syndrome
Familial adenomatous polyposis (FAP)
Lynch syndrome
Various genetic mutations.
Other ailments and conditions which might cause Stomach Cancer
Chronic atrophic gastritis, or long term stomach inflammation that makes the stomach lining thinner
Megaloblastic (pernicious) anaemiawhich might develop due to a deficiency of vitamin B12
Ménétrier’s Disease
Cancers in other parts of the digestive system
Epstein-Barr virus infection
Intestinalmetaplasia, in which cells usually line the intestine line the stomach lining undergo abnormal changes
Stomach ulcers[14]
Other Risk factors
Age 50 and above
Gender: Men are more at risk than women
Type A blood group
Stomach surgery for an ulcer
Symptoms of Stomach Cancer
Symptoms of stomach cancer may mimic other conditions such as Gastroesophageal Reflux Disease (GERD)[15], gastritis[16] or peptic ulcer which may delay detecting the condition earlier. If you or any of your near and dear suffer from the following symptoms repeatedly, or for longer durations of time, consult a doctor[17] and ask for stomach cancer screening.
Stomach cancer develops over different stages and the patient may suffer one or more of the following symptoms.
Severe, persistent heartburn[18]
Severe indigestion that is always present
Unexplained, persistent nausea
Difficulty in swallowing
Abdominal pain[19] or vague discomfort in the abdomen, usually above the navel
Nausea, vomiting and a bloated feeling after meals
Vomiting blood or blood in the stools
Diarrhoea or constipation[20]
Loss of appetite
Unexplained weight loss
Weakness and fatigue
Sense of fullness after eating small amounts of food (or early satiety)
Jaundice[21], yellowish eyes or skin
Excessive fatigue
Stomach pain, which may be worse after meals
Frequent burping
Pain in the breastbone
Trapped wind
Anaemia
Abuild-up of fluid in the stomach, which may cause the stomach to feel lumpy to the touch
Diagnosis
Upper endoscopy: A thin tube containing a tiny camera is passed down the throat and into stomach of the person. If any suspicious tissues are found, a piece of such tissue is collected for analysis, a procedure called as Biopsy.
Also Read: What is endoscopy? What are the different types of endoscopy?[22]
Imaging tests:Computerized tomography (CT), positron emission tomography (PET) and MRI (magnetic resonance imaging) scans are used to look for stomach cancer.
Exploratory surgery:The doctor may recommend surgery to look for signs that the cancer has spread beyond theoesophagus or stomach, within the chest or abdomen. The procedure is usually laparoscopic. That is, the surgeon makes several small incisions in the abdomen and inserts a special camera that transmits images to a monitor in the operating room.
Barium swallow:Also called asupper GI series test. The person must consume a drink containing barium. The fluid coats the stomach which makes it easy to show up very clearly in X-rays.
Stool tests: Also called faecal occult blood test, this is used to detect the presence of blood in the stoolswhich might not be visible to the naked eye.
Also Read: Tests to diagnose stomach problems[23]
Stomach cancer treatment
Treating stomach cancer has two purposes: one is to destroy the cancerous tissue completely and secondly, to prevent its spread to lungs, lymph nodes, bones and liver. Depending on which stage the cancer is at currently, treatment options include:
Surgery[24]: Depending on which part of the stomach is affected and how wide is the spread, there are various options such as endoscopic mucosal resection, subtotal gastrectomy and total gastrectomy.
Chemotherapy[25]: In this, chemicals are injected into the body to either shrink the tumour before surgery, destroy any cancerous cells left behind after the surgery, or to destroy cancerous cells that might have spread to the rest of the body.
Radiation therapy[26]: In this method, X-rays and proton streams are irradiated on the target area to destroy the cancerous cells.
Immunotherapy: In this method, certain drugs are given to attack specific abnormalities in cancer cells or vaccines are given to increase the person’s immunity level. Depending on which type of stomach cancer and what stage it is in, these drugs include Herceptin, Cyramza, Gleevec, Sutent, Stivarga, etc.
Conclusion
Stomach cancer can be successfully treated when detected in the early stages. Watch out for any of the symptoms and do not take them lightly. Consult your family physician[27] and discuss these symptoms with him/her. Needless to say, he/she will refer you to the right doctors or institution, for a successful treatment and rehabilitation.
Frequently Asked Questions
1. What are the common symptoms of stomach cancer?
Symptoms include severe indigestion, persistent nausea, difficulty swallowing, abdominal pain, vomiting blood, unexplained weight loss, and jaundice.
2. How is stomach cancer diagnosed?
Diagnosis methods include upper endoscopy (biopsy), imaging tests like CT scans, exploratory surgery, barium swallow, and stool tests.
3. What are the treatment options for stomach cancer?
Treatment includes surgery (endoscopic mucosal resection, gastrectomy), chemotherapy, radiation therapy, and immunotherapy, depending on the cancer’s stage.
4. What are the risk factors for stomach cancer?
Risk factors include lifestyle choices (alcohol, tobacco, diet), genetics (family history, specific syndromes), and other conditions like H. pylori infection and chronic gastritis.
5. How can stomach cancer be prevented?
Prevention involves maintaining a healthy lifestyle, avoiding risk factors like smoking and heavy alcohol consumption, and seeking regular medical check-ups for early detection.
Kauvery Hospital is globally known for its multidisciplinary services at all its Centers of Excellence, and for its comprehensive, Avant-Grade technology, especially in diagnostics and remedial care in heart diseases, transplantation, vascular and neurosciences medicine. Located in the heart of Trichy (Tennur, Royal Road and Alexandria Road (Cantonment), Chennai, Hosur, Salem, Tirunelveli and Bengaluru, the hospital also renders adult and pediatric trauma care.
What is endoscopy? What are the different types of endoscopy?: https://www.kauveryhospital.com/blog/k-way-health/what-is-endoscopy-what-are-the-different-types-of-endoscopy/
Tests to diagnose stomach problems: https://www.kauveryhospital.com/blog/k-way-health/tests-to-diagnose-stomach-problems/