Macklin effect – A Rare Occurrence in ICU

by admin | September 11, 2024 5:40 am

Abstract 

Presence of free air in pleural cavity is called as pneumothorax. Macklin effect refers to passage of air from damaged alveoli along the bronchopulmonary tracts towards proximal end & leaks to mediastinum by hilum. This case report demonstrate the timely intervention of spontaneous pneumothorax with a multi- disciplinary approach

Introduction 

Spontaneous pneumothorax occurs without a clear cause, such as trauma or medical intervention. It is classified into two types: primary and secondary. Primary spontaneous pneumothorax (PSP) arises in individuals without a prior history of lung disease, while secondary spontaneous pneumothorax (SSP) is linked to an existing pulmonary condition. A feared complication is tension pneumothorax. Here we present a case of primary spontaneous pneumothorax treated in our ICU.

Case report 

This is about a 53-year-old female patient who had a previous stroke (left ganglio capsular bleed) now on tracheostomy with nasogastric tube feeding. Patient underwent check OGD scopy to rule out esophageal stricture. Procedure was uneventful & there were no abnormalities detected. Post procedure patient developed hypoxia in recovery room and so patient was immediately shifted to ICU. POCUS revealed absent lung sliding on right side and chest x-ray confirms the diagnosis the diagnosis of right pneumothorax with small pneumomediastinum (Fig 1). Emergency ICD was placed. Patient was gradually weaned from mechanical ventilator. Right lung has expanded in 3 days and ICD was removed subsequently and shifted to ward.

Discussion 

Spontaneous pneumothorax is a multifactorial process and has been associated with rises in transpulmonary pressure and defects in the visceral pleura. Acute increases in alveolar pressure that exceed the pulmonary interstitial pressure can lead to alveolar rupture and pleural air leakage (3). Furthermore, points of weakness in the visceral pleura due to subpleural blebs, bullae, lung necrosis, and other connective tissue abnormalities can predispose the alveoli to rupture in both types of spontaneous pneumothorax, though the exact mechanism of how is not entirely understood (4). Macklin effect refers to tracking of air from ruptured alveoli along the peribronchovascular interstitium towards hila and finally enters mediastinum (5,6). Small primary pneumothorax can be managed conservatively with supplemental oxygen with follow up chest radiography. Large primary pneumothorax needs chest tube insertion. Recurrent pneumothorax needs VATS.

Conclusion 

The Macklin effect can be frequently observed on the MDCT images of patients with SPM not associated with trauma. A Macklin effect seen on CT may help differentiate respiratory from other etiologies of pneumomediastinum.

Referances 

a. Baig MA, Majeed MB, Attar BM, Khan Z, Demetria M, Gandhi SR. Efficacy and Safety of Indwelling Pleural Catheters in Management of Hepatic Hydrothorax: A Systematic Review of Literature. Cureus. 2018 Aug 06;10(8):e3110. [PMC free article: PMC6175258] [PubMed: 30338185]

b. Ojeda Rodriguez JA, Hipskind JE. StatPearls [Internet]. StatPearls Publishing; Treasure Island (FL): Aug 8, 2023. Iatrogenic Pneumothorax. [PubMed: 30252313]

c. Walker SP, Bibby AC, Halford P, Stadon L, White P, Maskell NA. Recurrence rates in primary spontaneous pneumothorax: a systematic review and meta-analysis. Eur Respir J. 2018 Sep;52(3) [PubMed: 30002105]

d. Bertolaccini L, Congedo MT, Bertani A, Solli P, Nosotti M. A project to assess the quality of the published guidelines for managing primary spontaneous pneumothorax from the Italian Society of Thoracic Surgeons. Eur J Cardiothorac Surg. 2018 Nov 01;54(5):920-925. [PubMed: 29788194]

e. Wintermark M, Wicky S, Schnyder P, Capasso P. Blunt traumatic pneumomediastinum: using CT to reveal the Macklin effect. AJR Am J Roentgenol. 1999;172:129–130. [PubMed] [Google Scholar]

f. Macklin MT, Macklin CC. Malignant interstitial emphysema of the lungs and mediastinum as an important occult complication in many respiratory diseases and other conditions: interpretation of the clinical literature in the light of laboratory experiment. Medicine. 1944;23:281–358. [Google Scholar]

 

Dr Dinesh
DrNB Critical Care Medicine Trainee
Kauvery Hospital Chennai

Source URL: https://www.kauveryhospital.com/ima-journal/ima-journal-september-2024/macklin-effect-a-rare-occurrence-in-icu/