A case report on Multiple myeloma: Value of pre and post-treatment MRI
S. Babu Peter1, Firdhous Begum2
1Senior Consultant Radiologist, Kauvery Hospital, Alwarpet, Chennai
2Junior Resident, Department of Radiology, Kauvery Hospital, Alwarpet, Chennai
Abstract
In this report, we present a 71-year-old male patient, with Multiple Myeloma, who presented to the Radiology department at Kauvery Hospital, Alwarpet, Chennai, India with complaints of severe backache and paraesthesia in both lower limbs.
There was a history of Left rib fracture (RTA) on 29/03/24. MRI whole spine taken on April 9, 2024 showed multifocal, discrete, bone marrow T2 hyperintense/T1 hypointense bone lesions involving the cervical, dorsal, and lumbar vertebrae, and clivus, as well as the visualized sections of the femur and ribs. MRI dorsal spine taken on June 11, 2024, after treatment, revealed significant/unequivocal reduction of bone marrow STIR hyperintense lesions as well as foci of restricted diffusion in the vertebrae and pelvis with development of fat halo sign (T1 WI) in few of the lesions. Relative reduction in size of the left posterior 8th rib lesion was also noted. This case is being reported to highlight the increased importance of MRI in the evaluation of Multiple Myeloma and follow-up, for assessment of response to treatment
Introduction
Multiple Myeloma (MM), also known as plasma cell myeloma, is a multifocal proliferation of plasma cells based in the bone marrow. It is the most common primary malignant bone neoplasm in adults. MM arises from red marrow due to the monoclonal proliferation of plasma cells and manifests in a wide range of radiographic abnormalities.
MM encompasses three main stages: monoclonal gammopathy of undetermined significance (MGUS), smouldering MM, and MM itself. Approximately 3–4% of the population older than 50 years has MGUS, and in approximately 20% of these patients, MGUS will progress to MM or a related condition within 25 years [1].
MRI is considered the most effective imaging method for evaluating bone marrow involvement in multiple myeloma before the mineralized bone tissue is destroyed [2]. It is the preferred procedure for assessing painful complications and/or spinal cord compression in patients with multiple myeloma. Additionally, MRI is the best non-invasive technique for differentiating neoplastic vertebral fractures from osteoporotic vertebral fractures [3].
Case Presentation
A 71-year-old male, with a known history of multiple myeloma, presented to our hospital with complaints of severe backache with paraesthesia in both lower limbs and was referred for a plain MRI whole spine to assess the severity of the disease.
MRI was performed in a Siemens 1.5T MRI machine. MRI showed multifocal discrete bone marrow T2 hyperintense/T1 hypointense lesions involving the cervical, dorsal, and lumbar vertebrae and clivus.
Fig (1): Initial Plain MRI –Sagittal sections
(A, B):T1w imaging of dorsal and lumbar spine show multiple discrete hypointense bone lesions (red arrow). Also, note moderate compression of D7 vertebral body (yellow arrow).
(C): T2w imaging of cervical spine show multiple discrete hyperintense lesions along with diffuse marrow signal changes in cervical vertebrae and clivus (red arrow).
Moderate degree compression of D7 vertebral body with no significant posterior retropulsion causing spinal canal compromise noted. Mild degree compression of D12 vertebral body without posterior retropulsion was noted. Relatively expansile lytic lesion noted involving the posterior aspect of left 8th rib.
Fig (2). Axial section of the T1w MRI shows isointense lytic lesion in posterior aspect of left eighth rib (blue arrow).
Multiple lesions are also noted involving the sacral and iliac bones as well as the visualized sections of the femur and ribs. Focal intramedullary T2 hyperintensities noted at C6-C7 level with relatively reduced calibre of the cervical spinal cord at that level – Likely myelomalacic changes.
Fig (3). Coronal section STIR image show multiple discrete hyperintense lesions in sacrum and ilium (blue arrow).
Fig (4). The sagittal section of dorsal spine DWI shows multiple discrete foci of restricted diffusion with ADC values (red arrows)
The patient came for follow-up imaging after 2 months, having completed 7 cycles of chemotherapy (7 cycles-Inj. Bortezomib). MRI whole spine was done as per the earlier protocol.
Present follow-up MRI revealed a significant reduction in the vertebral lesions with only very few discrete bone marrow T1 hypointense lesions involving the cervical, dorsal, and lumbar vertebrae and clivus.
Few of the lesions show emergence of peritumoral fat around the lesions (FAT HALO SIGN). No abnormal STIR hyperintense bone marrow lesions noted in sacral and iliac bones as well as the visualized sections of the femur and ribs, as compared to the earlier MRI Scan.
Compression fractures of D7 and D12 vertebrae remained the same. Relative reduction in size of the left posterior 8th rib lesion was seen.
The follow up MRI features were in favou of High likely to be responding to chemotherapy. (Myeloma Response Assessment and Diagnosis System – MY-RADS).
Fig (5): Sagittal sections of T2 w imaging shows few discrete hypointense lesions (orange arrow) in cervical, dorsal and lumbar vertebrae and clivus. (Compared to previous MRI, there is decrease in size and number of lesions)
Fig (6): A – STIR coronal section shows no evidence of hyperintense lesions in sacrum and ilium. B – Peritumoral fat (Fat Halo Sign) seen around the hypointense lesion in dorsal vertebrae (red arrow)
Fig (7): Sagittal section of dorsal spine high diffusion signal in DWI with high ADC values.
Discussion
Multiple myeloma (MM) is a plasma cell dyscrasia characterized by the proliferation and accumulation of monoclonal plasma cells. The disease progresses through several distinct stages:
- Monoclonal Gammopathy of Undetermined Significance (MGUS): An asymptomatic, premalignant stage.
- Smouldering Multiple Myeloma (SMM): An intermediate stage between MGUS and symptomatic MM.
- Symptomatic Multiple Myeloma: The final stage, characterized by end-organ damage such as hypercalcemia, renal impairment, anemia, and bone disease [4].
The diagnosis of MM primarily relies on the demonstration of bone marrow plasmacytosis and/or the presence of monoclonal proteins (M-proteins) in the serum or urine, as well as the detection of end-organ damage, particularly lytic bone lesions. This diagnostic approach is based on the International Myeloma Working Group (IMWG) diagnostic criteria reported in 2014 [5].
Bone disease is a significant feature of multiple myeloma (MM) and should be evaluated in all patients suspected of having MM. Most common sites are axial skeleton including vertebral bodies, skull, pelvis and ribs. Other sites include proximal metaphysis of long bones.
Imaging features include lytic lesions, diffuse osteopenia, endosteal scalloping, neoplastic and osteoporotic fractures, cortical disruption, and extraosseous involvement.
When evaluating bone marrow involvement in multiple myeloma (MM), T1-weighted MRI is typically the best choice. This is because bone marrow has a high fat content, especially in elderly patients, and T1-weighted imaging is well-suited for visualizing these fatty changes. Low signal intensity on T1-weighted images. Intermediate to high signal intensity on T2-weighted and STIR (Short Tau Inversion Recovery) images [6]. Enhancement after the administration of gadolinium-based contrast. High signal intensity on DWI with low ADC are the imaging features.
Weight-Bearing (WB) Radiography has been the reference standard method for evaluating Multiple Myeloma (MM) for the past decade. Despite its widespread use, WB radiography has very low rates of accuracy, particularly since destruction of 30–50% of the bone is necessary to detect a lesion. This results in a significant number of false-negative results, ranging from 30–70% [7].
Computed Tomography (CT) is more sensitive than radiography for detecting extra medullary lesions and evaluating areas of instability with an elevated risk of fractures. Whole Body Low Dose CT (WBLD CT) is less expensive and is very quick and easy to perform, involves low dose radiation protocol, with an acquisition time of 40–60 seconds [8].
Computed Tomography (CT) has a relatively weak negative predictive value, at 58.8% [9]. This means that if no bone lesions are detected on a Whole-Body Low Dose CT (WBLD CT), a follow-up investigation with a body MRI should be performed to rule out the presence of lesions.
MRI remains the best imaging method for evaluating bone marrow involvement before the mineralized bone tissue is destroyed. Whole Body MRI (WB MRI) is also more sensitive than Positron Emission Tomography/Computed Tomography (PET/CT) for detecting focal or diffuse bone involvement and large numbers of focal lesions. Therefore, MRI is the reference standard method for bone marrow assessment.
Moreover, MRI is the procedure of choice for evaluating painful complications and/or spinal cord compression in multiple myeloma (MM) and the best non- invasive technique for differentiating neoplastic from osteoporotic vertebral fractures.
Although it is not mandatory to use Diffusion Weighted MRI (DW MRI) routinely in clinical practice, the results of many studies have shown that this examination adds sensitivity in the detection of focal lesions. Additionally, DW MRI is a relatively fast sequence and does not require the use of contrast material, making it innocuous to patients and providing relevant information.
Dynamic contrast-enhanced imaging is another MRI technique that assesses the distribution of contrast agent inside and outside of blood vessels using computer-based analysis. This method provides valuable information about the blood flow and permeability of the bone marrow, which is essential for diagnosing and managing MM.
The time-intensity curves generated by dynamic contrast-enhanced imaging can be classified into five types. Type 4 curves are typically seen in MM infiltration into bone marrow, while type 3 and type 5 curves are less common. Type 1 and type 2 curves are typically seen in healthy individuals and those with monoclonal gammopathy of undetermined significance (MGUS) [10].
Few articles described PET/CT as being more effective than MRI in assessing treatment response. This is likely due to the differences in the underlying mechanisms. After treatment, changes in FDG (fluorodeoxyglucose) avidity occur earlier than the structural modifications seen on MRI.PET/CT can detect metabolically inactive lesions that appear positive on MRI, leading to a potential false-positive result with MRI [11].
Hence, Myeloma Response Assessment and Diagnosis System (MY-RADS) was designed to promote standardization and diminish variation in interpretation and reporting of MRI in myeloma.
It is based on the following descriptions provided by the Korean journal of radiology (doi.org/10.3348/jksr.2021.0179)(12).
Conclusion
Our case report highlights the values of MRI spine not only in the initial evaluation of multiple myeloma but also in the follow up after chemotherapy to assess response to treatment. MRI also plays a vital role to assess any spinal cord compression and other neurological complications.
As a result, MRI has become an indispensable tool in the management of multiple myeloma, guiding clinical decision-making and improving patient outcomes.
Reference
- Kumar SK. Rajkumar v, Kyle RA, et al. Multiple myeloma. nat Rev dis Primers. 2017;3(1):17046.
- Hillengass J, Landgren O. Challenges and opportunities of novel imaging techniques in monoclonal plasma cell disorders: imaging “early myeloma”. Leukemia & lymphoma. 2013 Jul 1;54(7):1355-63.
- Dimopoulos MA, Hillengass J, Usmani S, Zamagni E, Lentzsch S, Davies FE, Raje N, Sezer O, Zweegman S, Shah J, Badros A. Role of magnetic resonance imaging in the management of patients with multiple myeloma: a consensus statement. Journal of Clinical Oncology. 2015 Feb 20;33(6):657-64.
- Pratt G, Bowcock S, Chantry A, Cook G, Jackson G, Lai M, Low E, Mulholland N, Owen R, Rabin N, Ramasamy K. Time to redefine myeloma. British Journal of Haematology. 2015 Oct;171(1):1-0.
- Koutoulidis V, Fontara S, Terpos E, Zagouri F, Matsaridis D, Christoulas D, Panourgias E, Kastritis E, Dimopoulos MA, Moulopoulos LA. Quantitative diffusion-weighted imaging of the bone marrow: an adjunct tool for the diagnosis of a diffuse MR imaging pattern in patients with multiple myeloma. Radiology. 2017 Feb;282(2):484-93.
- Dutoit JC, Verstraete KL. MRI in multiple myeloma: a pictorial review of diagnostic and post-treatment findings. Insights into imaging. 2016 Aug;7:553-69.
- Giles SL, Desouza NM, Collins DJ, Morgan VA, West S, Davies FE, Morgan GJ, Messiou C. Assessing myeloma bone disease with whole-body diffusion-weighted imaging: comparison with x-ray skeletal survey by region and relationship with laboratory estimates of disease burden. Clinical radiology. 2015 Jun 1;70(6):614-21.
- Ippolito D, Besostri V, Bonaffini PA, Rossini F, Di Lelio A, Sironi S. Diagnostic value of whole-body low-dose computed tomography (WBLDCT) in bone lesions detection in patients with multiple myeloma (MM). European Journal of Radiology. 2013 Dec 1;82(12):2322-7.
- Kosmala A, Weng AM, Heidemeier A, Krauss B, Knop S, Bley TA, Petritsch B. Multiple myeloma and dual-energy CT: diagnostic accuracy of virtual noncalcium technique for detection of bone marrow infiltration of the spine and pelvis. Radiology. 2018 Jan;286(1):205-13.
- Dutoit JC, Vanderkerken MA, Verstraete KL. Value of whole body MRI and dynamic contrast enhanced MRI in the diagnosis, follow-up and evaluation of disease activity and extent in multiple myeloma. European journal of radiology. 2013 Sep 1;82(9):1444-52.
- Zamagni E, Nanni C, Patriarca F, Englaro E, Castellucci P, Geatti O, Tosi P, Tacchetti P, Cangini D, Perrone G, Ceccolini M. A prospective comparison of 18F-fluorodeoxyglucose positron emission tomography-computed tomography, magnetic resonance imaging and whole-body planar radiographs in the assessment of bone disease
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Prof. Dr. S. Babu Peter
Senior Consultant Radiologist
Dr. Firdhous Begum
Junior Resident
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- Learning from Experience – Chapters 7 and 8
- The Consultation Room
- Journal Scan
- Recommended Reading
- Diagnostic Video
- Poem from Staff Nurse
- Editorial
- March – the Month for Minds to dwell on Multiple Myeloma
- Covid Report
- Research Protocol
- New Arrows in our Quiver, to direct against SARS-CoV-2 variants
- Out-of-hospital cardiac arrest
- Last on the list: A diagnosis seldom considered in males
- Giant T wave inversion associated with Stokes: Adams syndrome
- Learning from Experience – Intra Operative, Chapters 9 and 10
- The Consultation Room
- Definitions of probability
- Journal Scan
- Recommended Reading
- Diagnostic Video
- A Thanksgiving to Cardiac Surgeons
- Editorial
- Kauverian eMedical Journal
- Research Article
- Research Protocol
- Saving the unsavable
- Case Report
- Case Report
- Letters to the Editor
- Diagnostic Image
- Learning from Experience – Intra Operative, Chapters 13 and 14
- The Consultation Room
- Journal Scan
- Recommended Readings
- Editorial
- Author Instruction
- SIGARAM – The Club for Children with Diabetes
- The hope for a better tomorrow
- An unusual complication of polytrauma:
- An enigma at the ER
- Dynamic examination of airway
- Journal Club
- Journal Club
- Journal Club
- Conditional Probability
- Diagnostic Image
- Learning from Experience – Intra Operative, Chapters 15 and 16
- The Consultation Room
- Journal Scan
- Recommended Readings
- EDITORIAL
- Kauverian eMedical Journal
- Junior nurses in Kauvery Hospital on the frontline against the COVID-19 pandemic
- Emergency Medicine, the Emerging Specialty: Leading Light on the entrance to the Health Care Pathway
- Battle of two drugs: Who won? – An unusual presentation
- Return of the native and a resurrected foe: A case of Rhinocerebral Mucormycosis
- Covert invader- atypical presentation of neuronal migration disorder
- Fragile heart: an unusual cause of chest pain
- Goldberger’s ECG sign in Left Ventricular Aneurysm
- Congenital absence of bilateral Internal Carotid Artery: A case report
- The Power of Purple
- Beads of Nature’s Rattle
- Case Report
- Diagnostic Image
- EDITORIAL
- Kauverian eMedical Journal
- Modification of Management Strategies, And Innovations, During SARS Cov2 Pandemic Improved the Quality, Criticality and Outcomes in In-Patients “Rising to the occasion”, the mantra for success in the COVID -19 pandemic
- Time in Range (TIR) In Diabetes: A Concept of Control of Glycemia, Whose Time Has Come
- Kauvery Heart Failure Registry- A Concept
- Shorter Course of Remdesivir In Moderate Covid-19 is as Efficacious as Compared to Standard Regime: An Observational Study
- CASE REPORT
- Lymphoepithelial Carcinoma: A Case Report of a Rare Tumour of The Vocal Cord
- Diabetic Keto Acidosis (DKA), Associated with Failed Thrombolysis with Streptokinase in Acute Myocardial Infarction
- EARNING FROM EXPERIENCE – CHAPTERS 1 AND 2
- The Consultation Room
- Journal scan
- Recommended Reading
- DIAGNOSTIC IMAGE
- Notes to Nocturne
- Editorial
- Kauverian eMedical Journal
- Caring for nobody’s baby
- Special Report
- Research Article
- The curious case of a migrating needle on the chest wall
- Foreign body: A boon at times
- Cardiorenal Syndrome
- What My Grandmother Knew About Dying
- Endovascular Therapy for Acute Stroke with a Large Ischemic Region. N Engl J Med. 2022
- Letter to the Editor
- Clinical outcomes of Coronary Artery Disease in Octogenarians
- Diagnostic Image
- Learning from Experience – Intra Operative, Chapters 11 and 12
- The Consultation Room
- Journal Scan
- Recommended Reading
- colours
- Editorial
- Author Instruction
- Ultrashort Case Report
- Cochlear Implantation: Expanding candidacy and Cost Effectiveness
- Spontaneous Pneumomediastinum in COVID 19 – Tertiary Care Centre Experience in South India
- Amoxycillin Induced Anaphylactic Shock: A Case Report
- An Unusual Cause of Seizures: A Case Report
- Case Report
- Educational Strategies to Promote Clinical Diagnostic Reasoning
- Rheumatic Rarities
- Types of sampling methods in statistics
- Diagnostic Image
- Learning from Experience – Intra Operative, Chapters 21 and 22
- The Consultation Room
- Journal Scan
- Recommended Readings
- Editorial
- Author Instruction
- Journal Scan
- Myeloma
- Posterior Reversible Encephalopathy Syndrome (PRES)
- Prophylactic orthopaedic surgery
- Subclavian steal: An interesting imaging scenario
- Spondylo-epi-metaphyseal dysplasia (SEMD)
- The bleeding windpipe
- Learning from Experience – Intra Operative, Chapters 23 and 24
- The Consultation Room
- Diagnostic Image
- Recommended Readings
- Editorial
- Editorial Board
- Physician, Protect thyself
- Foetal Medicine, the Future is here!
- Japanese Encephalitis: A common menace
- Carpometacarpal dislocation with impending compartment syndrome
- Heterotopic pregnancy
- Femoral Trochantric and Proximal Humerus Fracture, from Diagnosis to Rehabilitation
- My Father’s Heart Block
- EPS page
- CRT CSP Cases
- Journal scan
- Learning from Experience – Intra Operative, Chapters 25 and 26
- The Consultation Room
- Recommended Readings
- Editorial
- Editorial Board
- Multiple Sclerosis: An overview
- A flower born to blush unseen
- Guest Editorial
- Radio-frequency ablation as an effective treatment strategy in a case of VT storm post STEMI
- Lymphatic malformation of tongue
- Bilateral anterior shoulder dislocation in epilepsy: A case report and review of literature
- An unusual cause of Stridor
- Monoclonal Antibodies (mAbs) – the magic bullets: A review of therapeutic applications and its future perspectives
- Write the Talk
- Press release and Comments
- Probability Distribution of Bernoulli Trials
- Journal Scan
- Recommended Readings
- poem-v4i4
- Editorial
- Editorial Board
- Research
- Research
- Lambda-cyhalothrin and pyrethrin poisoning: A case report
- Good Enough
- The Monoclonal antibodies (mAbs): the beginning
- Comprehensive trauma course 2022: Trauma Management & Kauvery
- Comprehensive trauma course 2022: Introduction to Comprehensive trauma course
- Diagnostic Image
- Learning from Experience – Intra Operative, Chapters 27 and 28
- The Consultation Room
- Recommended Readings
- Poem
- Editorial
- The Brave New World of Anaesthesia
- Anesthetic considerations in Wilson’s disease for fess: A case report
- The painful story behind modern anaesthesia
- Anesthesia considerations for Ankyslosing Spondylitis
- Total intravenous anaesthesia: An overview
- Risk stratification for cardiac patients coming for non-cardiac surgeries
- The Anaesthesiologist’s role in fluoroscopic guided epidural steroid injections for low back pain
- Awake Craniotomy
- Malpositioned central venous catheter: Step wise approach to avoid, identify and manage
- Benefits outweighing risk: Neuraxial anaesthesia in a patient with Spina Bifida with operated Meningomyelocele
- Pain free CABG: newer horizon of minimally invasive cardiothoracic surgery a walk through anaesthesiologist perspective
- Stellate Ganglion Block: A bridge to cervical sympathectomy in refractory Long QT Syndrome
- Venous Malformation in Upper Airway – Anesthetic Challenges and Management: A Case Report
- Editorial
- USG guided peripheral nerve block in surgery for hernia
- Anaesthesia and morbid obesity: A systematic review
- Patient-Controlled Analgesia
- Parapharyngeal abscess of face and neck: Anesthetic management
- 3D TEE, a boon for the diagnosis of Left Atrial Appendage thrombus!
- Anaesthetic management of difficult airway due to retropharyngeal abscess and cervical spondylosis
- Expect the unexpected – Breach in continuous nerve block catheter
- Lignocaine nasal spray: An easy remedy for Post Dural Puncture Headache
- Potassium permanganate poisoning and airway oedema
- Angioedema following anti-snake venom administration
- Editorial
- Editorial Board
- Ra Fx ablation of Atrioventricular nodal reciprocating tachycardia
- Pace and Ablate Strategy: Conduction system pacing with AV junction ablation for drug refractory atrial arrhythmia – A novel approach
- Why Cardiac Resynchronization Therapy (CRT) For complete heart block? A case discussion
- Pacemakers and Bradyarrhythmias in Diabetic Mellitus
- Outcomes of Total Knee Arthroplasty in patients aged 70 years and above
- An approach to CBC for practitioners
- Acute cerebral sinus venous thrombosis with different presentations and different outcomes: A case series
- Diet and nutritional care for DDLT: A case study
- Vaccine for Dengue (Dengvaxia CYD-TDV)
- Diagnostic Image
- Learning from Experience – Intra Operative, Chapters 31 and 32
- Recommended Readings
- காவிரித்தாய்
- ATLAS OF HAEMATOLOGY AND HEMATOONCOLOGY
- Editorial
- Editorial Board
- Case reports and Case series:
- Usefulness of NEWS 2 score in monitoring patients with cytokine storm of COVID-19 pneumonia
- Treatment approach for extensively Drug-Resistant Tuberculosis (XDR-TB)
- Modified Lichtenstein mesh repair, for a patient of Coronary Artery Disease, Heart Failure and with Implanted Cardioverter- Defibrillator
- Fever-induced Brugada Syndrome
- Pulmonary Thrombo Embolism: When to Thrombolyse?
- Ultra-Short Case Report
- Learning from the failure of Nebacumab
- Journal scan
- Learning From Experience Intra Operative Chapters 29 and 30
- Recommended Readings
- Poem
- Editorial
- Editorial Board
- Heart transplantation: Life beyond the end of life
- Azithromycin to Prevent Sepsis or Death in Women Planning a Vaginal
- Medial retropharyngeal nodal region sparing radiotherapy versus standard radiotherapy
- Proximie: Patient safety in surgery – the urgent need for reform
- Analysis of femoral neck fracture in octogenarians and its management
- Adult Immunisation in Clinical Practice: A Neglected Life Saver
- “Icing” The Eyes
- Doppler vascular mapping in Arterio Venous Fistula (AVF)
- Cosmesis and cure: Radiotherapy in basal cell carcinoma of the dorsum of nose – A case report
- Pulmonary Hypertension and Portal Hypertension
- Comprehensive review of Drug-Induced Cardiotoxicity
- Statistics – Data Collection – Case Study Method
- Atlas of Haematology and Hematooncology
- PRE-OPERATIVE Chapters 1 and 2 – Learning from Experience
- Chapter 2. Uncertainties in medicine in spite of advances
- No Splendid Child
- Editorial
- Editorial Board
- A Young Girl Lost in the Storm
- ECMO as a bridge to Transplant: A case report
- Renal anemia – from bench to bedside
- Mission Possible
- New kids on the block – Update on diabetic nephropathy therapy
- Infections – Trade off in Transplants
- To Give Or Not to Give – Primer on Bicarbonate Therapy
- Sialendoscopy: Shifting paradigms in treatment of salivary gland disease
- Gait imbalance in a senior due to Chronic Immune Sensory Polyneuropathy (CISP)
- Statistics – Mcnemar Test
- Atlas Of Haematology And Hematooncology
- PRE-OPERATIVE Chapters 3 and 4 – Learning from Experience
- Changing trends a challenge to the already trained
- Journal scan
- Recommended Readings
- EDITORIAL
- EDITORIAL BOARD
- PREGNANCY POST-RENAL TRANSPLANT
- BALLOON-OCCLUDED RETROGRADE TRANSVENOUS OBLITERATION
- REVERSE SHOULDER ARTHROPLASTY FOR ROTATOR CUFF ARTHROPATHY
- THE AMBUSH A TEAM APPROACH
- ENDOSCOPIC TRANS-SPHENOID APPROACH FOR PITUITARY ADENOMA EXCISION
- A STUDY ON PRESENTATION AND OUTCOME OF BULL GORE INJURIES IN A GROUP OF TERTIARY CARE HOSPITALS
- A CASE OF INTERNUCLEAR OPHTHALMOPARESIS AS THE FIRST MANIFESTATION OF MULTIPLE SCLEROSIS
- GRANULOMATOSIS WITH POLYANGITIS AND LUNG INVOLVMENT (WEGENER’S DISEASE)
- RITUXIMAB (RITUXAN, MABTHERA) IN THE TREATMENT OF B-CELL NON-HODGKIN’S LYMPHOMA
- STATISTICAL SIGNIFICANCE
- Atlas Of Haematology And Hematooncology
- PRE-OPERATIVE CHAPTERS 5 AND 6 – LEARNING FROM EXPERIENCE
- Chapter 4: Diagnostic process often reversed
- Journal scan: A review of 25 recent papers of immediate clinical significance, harvested from major international journals
- Recommended Readings
- ஆரோக்கியம் நம் கையில்
- வெற்றியின் பாதை
- Editorial
- Editorial Board
- Prevalence of vitamin D deficiency in a multi-speciality hospital orthopaedic outpatient clinic
- Esomeprazole induced Hypoglycemia
- Dynamic external fixator for unstable intra articular fractures of Proximal Interphalangeal Joint (PIP): “Suzuki” frame
- How to Practice Academic Medicine and Publish from Developing Countries? A Practical Guide, Springer Nature, 2022
- WINTNCON 2022 – Scientific Program
- Pulmonary Thrombo Embolism: A state of the art review
- Role of Artificial Intelligence in improving EHR/EMR and Medical Coding and billing
- Monoclonal Antibodies: Edrecolomab and Abciximab
- Atlas of haematology and hematooncology
- Journal scan
- Learning from Experience – Intra Operative, Chapters 31 and 32
- What doctors must learn: Doctor, look beyond science
- Recommended Readings
- I Whisper Secrets In My Ear
- EDITORIAL
- Instructions for Authors
- Mismatched Haploidentical Bone Marrow Transplantation in a 10-year-old boy with relapsed refractory acute lymphoblastic leukemia, at Trichy
- ST-Segment Elevation is not always Myocardial Infarction
- Acyanotic Congenital Heart Disease, repaired, evolves into a Cyanotic Congenital Heart Disease and presents with an atrial tachycardia
- Family medicine – caring for you for the whole of your life. A Lost and Found Art
- The Principles and Practice of Family Medicine
- Complete Heart Block
- Sick Sinus Syndrome (SSS)
- The First Ever National Award Comes to Kauvery Hospital Chennai & Heart City for Safety and Workforce Category in IMC RBNQA Milestone Merits Recognition 2022
- Diagnostic Image
- PRE-OPERATIVE CHAPTERS 7 AND 7 – LEARNING FROM EXPERIENCE
- Chapter 5: Super-specialist – boon or bane
- Journal scan: A review of 42 recent papers of immediate clinical significance, harvested from major international journals
- RECOMMENDED READINGS
- நேரம் ஒதுக்கு
- மருத்துவரின் மகத்துவம்
- EDITORIAL
- Instructions for Authors
- Surgical Management of Covid-19 Associated Rhino-Orbito-Cerebral-Mucormycosis (Ca-Rocm) – A Single Centre Experience
- Knee Joint Preservation Surgeries
- Guest Editorial Comments
- Ventricular Septal (VSR) closure with ASD device
- Newer Calcium Debulking Angioplasty technique of Orbital Atherectomy
- An hour-long CPR to restart the heart
- VT or SVT with aberrancy?
- Pituitary Neuroendocrine Tumor (PitNET)
- VSD Device Closure
- PDA Device Closure
- Iron Deficiency Anemia, Post MVR
- Torsades de Pointes
- Quality improvement project to Reducing the Malnutrition Rate of ICU patients from 43% to 20%
- Long term use of Amiodarone in Cardiac patients: A Clinical Audit
- Statistical Independent Events and Probability
- PERI-OPERATIVE Chapters 9 and 10 – Learning from Experience
- Journal scan: A review of 40 recent papers of immediate clinical significance, harvested from major international journals
- EDITORIAL
- Kauverian Medical Journal
- First da Vinci Robotic Surgery in Carcinoma Prostate: A Case Report
- Black burden or Taylor the saviour: A case report
- Analysis of differences in Oncology practice between the United Kingdom and India
- A Case of Takayasu Arteritis
- Idiopathic Dilated Pulmonary Artery (IDPA)
- ECG Atlas
- Unusual cause of Dysphagia: A case report
- Tu Youyou: The scientist who discovered artemisinin
- Continuing Nursing Education (CNE) on Risk assessment tools, to assess vulnerable patients at Kauvery Hospital, Tennur
- DIAGNOSTIC IMAGE
- PRE-OPERATIVE CHAPTERS 11 AND 12 – LEARNING FROM EXPERIENCE
- OLD AND NEW – MAKE THE BEST OF THE TWO
- Journal scan: A review of 30 recent papers of immediate clinical significance, harvested from major international journals
- Recommended Readings
- EDITORIAL
- INSTRUCTION TO AUTHORS
- A pregnant patient with DKA, septic shock and a lactate mystery
- Radical Thymectomy in Myasthenia Gravis through Partial Sternotomy approach: A report on three patients
- In-utero blood transfusion in two etiologically distinct anaemic fetus
- RARE CAUSE OF PULMONARY HYPERTENSION
- Acute Rheumatic fever is still an enigma
- A remarkable journey: Managing LQTS in a 43-year-old female with recurrent syncope and seizure
- An unusual case of Acute Coronary Syndrome
- Reversible cause of severe LV Dysfunction in Left Bundle Branch Block
- A case study on Rhino-Orbital-Cerebro- Mucormycosis
- Snakebite and its management
- Total Elbow arthroplasty in Post Traumatic arthritis
- Wellens Syndrome: An ECG finding not to miss!
- Dr. C.R. Rao Wins Top Statistics Award a look back at his pioneering work
- PRE-OPERATIVE Chapters 13 and 14 – Learning from Experience
- Chapter 7. Doctor-patient relationship
- Journal scan: A review of 30 recent papers of immediate clinical significance, harvested from major international journals
- EDITORIAL
- INSTRUCTION TO AUTHORS
- FROZEN ELEPHANT TRUNK (FET) PROCEDURE IN A 52 YEARS OLD CHRONIC AORTIC DISSECTION PATIENT
- DIAGNOSING AND MANAGING EISENMENGER SYNDROME IN A YOUNG MALE
- STEMI EQUIVALENT BUT STEMI!
- TEMPORARY HEAL CAN POSSIBLY KILL!
- UNDERSTANDING PUBERTY
- THE IMPORTANCE OF STATISTICS IN HEALTHCARE
- JOURNAL SCAN: A REVIEW OF 44 RECENT PAPERS OF IMMEDIATE CLINICAL SIGNIFICANCE, HARVESTED FROM MAJOR INTERNATIONAL JOURNALS
- DIAGNOSTIC IMAGE
- PRE-OPERATIVE CHAPTERS 15 AND 16 – LEARNING FROM EXPERIENCE
- CHAPTER 8. DOCTOR-DOCTOR RELATIONSHIP
- EDITORIAL
- GUEST EDITORIAL
- CLINICAL AUDIT: AN INTRODUCTION
- YOUNG ACS AUDIT
- CLINICAL AUDIT: ANAESTHESIA
- CLINICAL OUTCOME IN ICU PATIENTS
- RATE OF MALIGNANCY IN INDETERMINATE OVARIAN CYST – A PROCESS AUDIT
- PATTERNS OF NEEDLE DISPOSAL AMONG INSULIN USING PATIENTS WITH DIABETES MELLITUS: AN AUDIT
- CONTINUOUS PATIENT MONITORING – LIFE SIGNS
- AGE IS JUST A NUMBER!
- SVT WITH LEFT BUNDLE BRANCH BLOCK FOLLOWING GASTRECTOMY
- COMPLEX AORTIC DISSECTION WITH MULTIFACETED CLINICAL PRESENTATIONS
- EDITORIAL
- POST-OPERATIVE SORE THROAT IN GA: A CONCERN
- NEONATAL HLH: OUR EXPERIENCE
- CLINICAL REVIEW MEET 16TH NOV 2023: CHALLENGES IN SETTING UP A NEW HSCT CENTRE IN A TIER-2 CITY IN INDIA
- CARDIAC BIOMARKERS: CLINICAL UTILITY
- HIRAYAMA DISEASE: A CLINICAL-RADIOLOGICAL REVIEW
- ECG AS A WINDOW OF OPPORTUNITY: FOR HYPERKALEMIA
- EFFECTIVENESS OF ROOD’S APPROACH BASED PAEDIATRIC OCCUPATIONAL THERAPY MANAGEMENT: ON CHILDREN WITH CONGENITAL MUSCULAR TORTICOLLIS
- ELTROMBOPAG, A NOVEL THROMBOPOIETIN (TPO) RECEPTOR AGONIST: AN OVERVIEW
- HENOCH-SCHONLEIN PURPURA
- SUBMANDIBULAR GLAND SIALADENITIS SECONDARY TO SUBMANDIBULAR CALCULUS
- LEAN HOSPITALS
- STATISTICS BLACK-SCHOLES MODEL
- PERI-OPERATIVE CHAPTERS 17 AND 18 – LEARNING FROM EXPERIENCE
- CHAPTER 9. BUILDING BLOCKS OF PATIENT CARE
- JOURNAL SCAN: A REVIEW OF 30 RECENT PAPERS OF IMMEDIATE CLINICAL SIGNIFICANCE, HARVESTED FROM MAJOR INTERNATIONAL JOURNALS
- EDITORIAL
- INSTRUCTIONS TO AUTHORS
- ROTATHON-SERIES OF SUCCESSFUL ROTA CASES LAST 2 MONTHS: AN AUDIT
- OUTCOMES OF AKI AUDIT IN KAUVERY
- ETIOLOGY, CLINICAL CHARACTERISTICS AND OUTCOMES OF PATIENTS WITH ACUTE PANCREATITIS IN KAUVERY CANTONMENT HOSPITAL (KCN), TRICHY
- USE OF BLOOD PRODUCTS AND STEROIDS IN THE MANAGEMENT OF DENGUE AT KAUVERY TRICHY HOSPITALS: A CLINICAL AUDIT
- A CLINICAL AUDIT: ON THE MANAGEMENT OF ECTOPIC PREGNANCY
- DIABETIC KETOACIDOSIS WITH HIGH ANION GAP METABOLIC ACIDOSIS
- HYPOKALEMIC PARALYSIS FROM DISTAL RENAL TUBULAR ACIDOSIS (TYPE-1)
- DELAYED PRESENTATION OF INTERMEDIATE SYNDROME IN A PATIENT WITH ORGANOPHOSPHORUS POISONING: A CASE REPORT
- SCAPULA FRACTURES: DO WE NEED TO FIX THEM?
- SPONTANEOUS CSF RHINORRHEA
- DANCING WITH DIABETES: AN UNUSUAL CASE OF CHOREA HYPERGLYCEMIA BASAL GANGLIA SYNDROME
- CONVALESCENT RASH OF DENGUE
- ECG ATLAS 2
- MI MIMICKER
- PERFORATION PERITONITIS-A CASE REPORT
- APPLICATION OF EVIDENCE BASED PRACTICE CARE FOR INDIVIDUALS WITH SPINAL CORD INJURY WITH FUNCTIONAL DIFFICULTIES: ROLE OF THE OCCUPATIONAL THERAPY PRACTICE GUIDELINES
- METHOTREXATE INDUCED MUCOSITIS AND PANCYTOPENIA: A CONSEQUENCE OF MEDICATION ERROR IN A PSORIASIS PATIENT
- POST OPERATIVE CHAPTERS 1 AND 2 – LEARNING FROM EXPERIENCE
- CHAPTER 10. NURTURING SELF
- விடாமுயற்சி வெற்றி தரும்
- JOURNAL SCAN: A REVIEW OF 26 RECENT PAPERS OF IMMEDIATE CLINICAL SIGNIFICANCE, HARVESTED FROM MAJOR INTERNATIONAL JOURNALS
- EDITORIAL
- EDITORIAL BOARD
- LIMB SALVAGE IN EXTREMITY VASCULAR TRAUMA: OUR EXPERIENCE
- MANAGEMENT OF URETHRAL CATHETER RELATED PAIN IN RENAL TRANSPLANT RECIPIENTS: A CLINICAL AUDIT
- NO PAIN VEIN GAIN WITH PRILOX IN PAEDIATRIC POPULATION
- GUIDELINE-DIRECTED MEDICAL TREATMENT (GDMT) OF HEART FAILURE AT KAUVERY HOSPITALS: A CLINICAL AUDIT
- PATIENTS STORY: DIGNITY MATTERS
- PATIENTS STORY: DIGNITY MATTERS
- VIDEO PRESENTATION- CT CORONARY ANGIOGRAPHY
- DRUG INDUCED HYPERKALEMIA
- ADULT NEPHROTIC SYNDROME
- EXPLORING COMPLEX CARDIAC CASES: INSIGHTS FROM DIVERSE PRESENTATIONS IN MID-AGED WOMEN
- EFFECTIVENESS OF ACTIVITY CONFIGURATION APPROACH BASED OCCUPATIONAL THERAPY INTERVENTION FOR CHILDREN WITH CONGENITAL MUSCULAR TORTICOLLIS: A CASE STUDY
- CARDIOMYOPATHY AND ITS ECHO FINDINGS
- THE STRESS TEST ON THE TREADMILL
- POST OPERATIVE CHAPTERS 3 AND 4 – LEARNING FROM EXPERIENCE
- CHAPTER 11. BALANCE IN LIFE BEYOND BANK BALANCES
- JOURNAL SCAN: A REVIEW OF 30 RECENT PAPERS OF IMMEDIATE CLINICAL SIGNIFICANCE, HARVESTED FROM MAJOR INTERNATIONAL JOURNALS
- காணும் பொங்கலும் மனித மன மாற்றமும்
- EDITORIAL
- INSTRUCTIONS TO AUTHORS
- PREVALENCE OF STREPTOCOCCUS PNEUMONIAE SEROTYPES IN AND AROUND TRICHY AND ITS CLINICAL RELEVANCE
- ANAESTHETIC MANAGEMENT OF A PATIENT WITH HUGE GOITER: A CASE REPORT
- EUGLYCEMIC DIABETIC KETOACIDOSIS A RARE CAUSE FOR DELAYED EXTUBATION
- SUCCESSFUL PREGNANCY IN ASD PATIENT – COMPLICATED BY SEVERE PULMONARY ARTERIAL HYPERTENSION
- ENDOCRINE COMPLICATION OF GROWTH HORMONE SECRETING TUMOR: A CASE REPORT
- EFFICACY OF EARLY DIAGNOSIS AND DEVELOPMENT APPROACHES OF PAEDIATRIC OCCUPATIONAL THERAPY ON ACUTE DISSEMINATED ENCEPHALOMYELITIS: A CASE REPORT
- POST OPERATIVE CHAPTERS 5 AND 6 – LEARNING FROM EXPERIENCE
- CHAPTER 12. MILES TO GO – BEFORE TEACHING BECOMES LEARNING
- JOURNAL SCAN: A REVIEW OF 26 RECENT PAPERS OF IMMEDIATE CLINICAL SIGNIFICANCE, HARVESTED FROM MAJOR INTERNATIONAL JOURNALS
- காவேரி – 25
- POEM – மண்ணில் பிறந்தது சாதிப்பதற்குத்தான்
- Editorial
- Video – Left main disease: Is it still a Surgeons Domain
- Propofol and the unspoken pain
- Thrombocytopenia in pregnancy: Experience from a tertiary care centre of a tier 2 city in South India
- Snake envenomation and its managements
- Essentials of Advanced Cardiac Life Support
- Video – Sepsis Management
- The phantom Block: Ogilvie’s
- Airway Management in an Adult with Subglottic Stenosis: Overcoming Ventilation Challenges with a Small Endotracheal Tube ”
- Descending thoraco-abdominal aortic aneurysm rupture with left massive hemothorax –diagnosis and emergency management
- C-IIH (Chronic IIH Imaging in Headache) study: Hospital-based pictorial review of Chronic IIH variants Neuroradiologist’s perspective
- Diagnostic Image: Small bowel diverticulosis
- Occupational therapy interventions for Schizophrenia: A systematic review
- Post-Operative Chapters 23-25
- Chapter 21. How to communicate need for further tests or referral for second opinion?
- Journal scan: Journal scan: A review of 13 recent papers of immediate clinical significance, harvested from major international journals
- Poem- கருணையின் வடிவமே தானம்
- Poem – நீ உன்னையறிந்தால்
- EDITORIAL
- EDITORIAL BOARD
- Audit Appraisal: An overview
- Intra Ventricular antibiotics: Our experience
- Transfusion Reactions: A clinical audit
- Postoperative pain management
- Rising concerns of Carbapenem resistant Enterobacteriaceae and the options available: An overview
- Ultrashort case report on VF storm in immediate Post CABG Period—‘Angry Purkinje Syndrome’
- Lynch syndrome, diagnostic challenges and management: A case report
- Bilateral posterior shoulder fracture – dislocation due to seizure, an uncommon injury: A case report
- Navigating amlodipine overdose: A multi-disciplinary approach in a 23 year old female
- Exploring the interplay between sleep patterns and behavioural characteristics in individuals with Autism Spectrum Disorder (ASD)
- POST OPERATIVE Chapters 7 and 8 – Learning from Experience
- Chapter 13. Art of communication and counselling
- Journal scan: A review of 20 recent papers of immediate clinical significance, harvested from major international journals
- மருத்துவமனையின் தேவதையே
- மருத்துவ சிந்தனை விருந்து
- Editorial
- Instructions for Authors
- Cardiac surgery in an octogenarian Indian population
- Mycotic Aortoiliac Aneurysm: A case series
- The Scorpion Block—A Sting operation
- Arterial Thoracic Outlet Syndrome: A case report
- Infective endocarditis in adult congenital heart disease: A case report
- Takotsubo cardiomyopathy: A case report
- Cerebral Venous Thrombosis (CVT): A case report
- Hemophagocytic Lymphohistiocytosis in Dengue
- A prospective observational study on the prescription of Guideline Directed Medical Treatment (GDMT) for Heart Failure at Kauvery Heart City
- Guideline-Directed Medical Treatment (GDMT) of Heart Failure at Kauvery Hospitals: A clinical audit
- POST OPERATIVE Chapters 9 and 10 – Learning from Experience
- Chapter 14. How to keep updated in busy medical practice?
- Journal scan: A review of 15 recent papers of immediate clinical significance, harvested from major international journals
- சிந்தனையே சிறப்பு
- தோல்வியே வெற்றியின் பாதை
- Editorial
- Results of Mechanical Thrombectomy in acute stroke: A case study in a Tier 2 city in India
- A clinical audit—cost effective way of managing superficial chest wound infections post sternotomy
- Dental implants: Our experience and expertise
- A non-randomized retrospective study on the management of pediatric septic arthritis
- Analysis of femoral neck fracture in octogenarians and its management
- Airway management of a huge thyroid: A case report
- Cardiac Arrhythmias in the ER setting
- Effectiveness of tactile-spatial oriented approach based paediatric occupational therapy intervention for children with Infantile Hemiplegia
- Corporate citizenship in healthcare: Nurturing social responsibility
- Guillain-Barré syndrome: A case report
- POST OPERATIVE Chapters 11 and 12 – Learning from Experience
- Chapter 15. How to be rational in practice?
- Journal scan: Elsevier’s Medicine, Current Issue, Volume 52 Issue 6, June 2024, Seminar on Poisoning
- Recommended Readings
- இயற்கை சொல்லும் செய்தி
- Editorial
- Instructions for Authors
- A rare organism causing septic arthritis of hip joint
- ICD implant in 6 year old with Jervell and Lange-Nielsen (JLN) syndrome
- A clinical audit on Bariatric/Metabolic surgery
- Clinical audit on Nil per Oral (NPO)
- A non-randomized clinical study on heat stroke
- Stress cardiomyopathy with posterior reversible encephalopathy syndrome in Eclampsia
- Intro-Reversible Cerebral Vasoconstriction Syndrome (RCVS): An ultra-short case report
- A 2 am Tamponade: Critical call to action
- Immune Checkpoint Inhibitors, and in combination with JAK inhibitors: The modelling for the future
- Optimizing the patient journey in hypertrophic cardiomyopathy—Patient and clinician perspectives: Summary of CME from Medscape
- ER Intervention
- Diagnostic Images/Videos
- A randomized controlled trial: Different types of blinding
- Journal scan – June
- Journal scan – July
- Post-Operative Chapters 13, 14
- Chapter 16. How to enjoy medical practice?
- Driving business growth with 5S and lean strategies: A transformative session for corporations in the Trichy region
- Poem: 25 – வருடங்களாக காவேரி
- Editorial
- A Data Audit: Tool for Good Clinical Practice
- Ortho rehab audit at Kauvery Hospital, Trichy
- Endovascular Thrombectomy in young patient with a stroke – surgical procedure decompressive craniotomy
- Secondary HLH (Hemophagocytic Lymphohistiocytosis): An ultra-short case report
- Prone ventilation: A case series
- Dermatologic Emergencies: A case series
- Managing DKA at the ER
- Podcast – Managing DKA at the ER
- Insertion of tunneled hemodialysis catheter through the collateral vein adjacent to the thrombosed right jugular vein.
- Access failure with dysfunctional tunnelled haemodialysis catheter in the presence of exit-site infection
- Video – A multidisciplinary approach to preventing sudden cardiac death
- Dasatinib in pediatric Chronic Myeloid Leukemia: An overview
- Dyslipidemia management: Indian perspective
- Pharmacological stress testing: Assessing heart health without exercise
- Journal scan: A review of 15 Ethics with clinical significance, harvested from a major international journal
- Post-Operative Chapters 15 and 16
- Chapter 17. How to find time for the family
- Poem – உனக்காக நீ
- Editorial
- An audit: A silent disease-Osteoporosis
- An approach to antibiotic therapy: A primer for all specialties
- Audit on pediatric Cholesteatoma
- Clinical audit: ER to ICU transit time
- A case report on Multiple myeloma: Value of pre and post-treatment MRI
- Unrelated donor bone marrow transplantation in 3 year old with Acute Myeloid Leukemia
- Infective endocarditis: A case series
- A Retrospective observational study on Scrub typhus paediatric population in Kauvery Hospitals, Trichy
- Clinical Pharmacy Approach: To a patient on multiple anticonvulsants for “Difficult to control’’ seizure disorder
- An analysis of the Urea to Creatinine Ratio (UCR) in different cardiac surgeries
- Journal scan – 1
- Journal Scan – 2
- Post-Operative Chapters 17 and 18
- Chapter 18. How to be legally safe in medical practice?
- Poem – காவேரியின் மாரத்தான்
- Poem – ஆரோக்கியம் என்னுடையது
- Editorial
- Clinical audit on antibiogram
- Renal transplantation in marrow dysfunction: A case series
- Empowering lifesavers: Impact of BLS and PALS training for PICU and critical care nurses
- Myotonia congenita: A case series
- Utilization of Inj. Sovateltide: A novel injectable formulation
- Retroperitoneal sarcoma: A report of two cases
- Traumatic simultaneous bilateral femur and tibia shaft fracture in an 8-year-old male child: An unusual case report
- Echocardiography in the assessment of shock
- Plasma combats angioedema: A case report
- A case report and video presentation on a 9-year-old boy who underwent PAPVC
- Interventional Radiology: Large gastric varices
- Interventional Radiology: A case of active PV bleeding post-D and C day 12
- Diagnostic Images: Exencephaly
- A short case report on Hyperdontia (extra teeth)
- Post-Operative Chapters 19 and 20
- Chapter 19. How to deal with incurable disease?
- CII CFO Excellence award: A recognition of exceptional leadership
- Journal scan
- Poem – மறுக்காதே மறவாதே
- Editorial
- An audit: Microvascular Free Flaps
- DSME Programs – Lessons learned
- Surgical Reconstruction Of Acromio Clavicular Joint Dislocation Using Double Endobutton – A Case Report
- Complex Iliac Artery And Venous Reconstruction In Case Of Polytrauma – Case Report
- Basics of statistics- from of a clinician’s perspective
- A comprehensive review on Rabies: Clinical aspects and treatment
- Lateral Medullary Syndrome – Case Report
- Postpartum ischemic stroke – case report
- Proning Saves Lives
- Video – A challenging case of Recurrent craniopharyngioma with supra and infra tentorial cyst and hydrocephalus
- Event: Update on Atrial Fibrillation
- Investigating the Role of Activity-Based Configurational Developmental approach in Managing Mitochondrial Leukodystrophy in Children
- Post-Operative Chapters 21 and 22
- Chapter 20. How to deal with failure of treatment
- Journal scan: A review of 12 recent papers of immediate clinical significance, harvested from major international journals
- Poem – தன்னம்பிக்கையும் விடாமுயற்சியும்
- Extraordinary Edition of the Kauverian